Published Research Papers

We have more than a decade’s worth of data on our stem cell procedures, and our patients are participants in the largest human mesenchymal stem cell (MSC) orthopedic re-implantation database in the world. Because of our long history in the field and commitment to research, Regenexx® has more data than any of our peer orthopedic stem cell providers. We analyze and report on outcome data from our patient registry on a regular basis and publish our findings in medical journals for our peers and patients to learn more about this growing practice. 

Medical Journal Articles Containing Regenexx Research

• Quantitation of progenitor cell populations and growth factors after bone marrow aspirate concentration.
  Journal of Translational Medicine
• Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentrationdependent manner
  Bone & Joint Research
• Quantitation of progenitor cell populations and growth factors after bone marrow aspirate concentration.
  Journal of Translational Medicine
• Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentration-dependent manner.
  Bone & Joint Research. (2019)
• A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis; a randomized control trial with 2 year follow-up.
  Journal of Translational Medicine
• A multi-center analysis of adverse events among two thousand, three hundred and seventy two adult patients undergoing adult autologous stem cell therapy for orthopaedic conditions.
  International Orthopaedics
• Symptomatic anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow concentrate and platelet products: a non-controlled registry study.
  Journal of Translational Medicine (2018)
• Treatment of lumbar degenerative disc disease-associated radicular pain with culture-expanded autologous mesenchymal stem cells: a pilot study on safety and efficacy.
  Journal of Translational Medicine (2017)
• The use of lumbar epidural injection of platelet lysate for treatment of radicular pain.
  Journal of Experimental Orthopaedics (2017)
• A New Atlanto-Occipital (C0-C1) Joint Injection Technique
  Pain Medicine (2017)
• Interventional Orthopedics in Pain Medicine Practice
  Techniques in Regional Anesthesia and Pain Management
• Intra-discal injection of autologous, hypoxic cultured bone marrow-derived mesenchymal stem cells in five patients with chronic lower back pain: a long-term safety and feasibility study.
  Journal of Translational Medicine (2016)
• Performing a Better Bone Marrow Aspiration.
  Physical Medicine and Rehabilitation Clinics of North America (2016)
• A Dose Response Analysis of a Specific Bone Marrow Concentrate Treatment Protocol for Knee Osteoarthritis.
  BMC Musculoskeletal Disorders (2015)
• Anterior Cruciate Ligament (ACL) Tears treated with Percutaneous Injection of Autologous Bone Marrow Nucleated Cells: A Case Series.
  Journal of Pain Research 2015: 8: 437-447
• Efficacy and Safety of Bone Marrow Concentrate for Osteoarthritis of the Hip; Treatment Registry Results for 196 Patients.
  Stem Cell Research and Therapy; Volume 4: Issue 10; 2014, Article ID 370621,. Centeno CJ.
• Efficacy of Autologous Bone Marrow Concentrate for Knee Osteoarthritis with and without Adipose Graft.
  BioMed Research International; Volume 2014, Article ID 370621,. Centeno CJ.
• A Prospective Multi-site Registry Study of a Specific Protocol of Autologous Bone Marrow Concentrate for the Treatment of Shoulder Rotator Cuff Tears and Osteoarthritis.
  Journal of Pain Research 2015:8 269–276
• Amide-Type Local Anesthetics and Human Mesenchymal Stem Cells: Clinical Implications for Stem Cell Therapy.
  Stem Cells Transl Med. 2014 Jan 16.
• Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells.
  Regenerative Sciences Inc (RSI), Centeno-Schultz Clinic, Westminster, CO 80020, USA.–Pain Physician. 2008 May-Jun;11(3):343-53.
• Clinical challenges and opportunities of mesenchymal stem cells in musculoskeletal medicine.
  PM R. 2014 Jan;6(1):70-7. doi: 10.1016/j.pmrj.2013.08.612. Centeno CJ.
• Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group.
  Wien Med Wochenschr. 2013 Aug 15.
• Safety and Complications Reporting Update on the Re-implantation of Culture-Expanded Mesenchymal Stem Cells using Autologous Platelet Lysate Technique.
  Centeno CJ, Schultz JR, Cheever M, Freeman M, Faulkner S, Robinson B, Hanson R.–Curr Stem Cell Res Ther. 2011 Oct 17.
• A Case Series of Percutaneous Treatment of Non-Union Fractures with Autologous, Culture Expanded, Bone Marrow Derived, Mesenchymal Stem Cells and Platelet Lysate
  Journal of Bioengineering and Biomedical Science. 2011
• Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells when BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone.
  J Orthop Res. 2010 Mar 22
• Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique.
  Curr Stem Cell Res Ther. 2010 Mar;5(1):81-93.
• Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells.
  Med Hypotheses. 2008 Dec;71(6):900-8. Epub 2008 Sep 10.
• Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer: A case study.
  Pain Physician. 2006 Jul;9(3):253-6.