Walk and Even Run Again without Painful Surgery

Foot and Ankle Treatments with Non-surgical Regenexx® Procedures

Regenexx® Procedures are non-surgical, injection-based procedures for patients who have foot and ankle injuries, arthritis, or other painful conditions. These procedures use concentrated repair cells obtained from your own bone marrow or blood to promote your body’s natural healing ability.

While many orthopedic surgeons recommend and perform tendon grafts to reinforce loose connections between the bones, ankle arthroscopies as a treatment for damaged cartilage or fusing ankle bones to replace lost cartilage, these are painful and may not yield long-lasting positive effects. In addition, after surgery, rehabilitation of the ankle could be a long and uncomfortable process. Regenexx may help reduce pain and improve function for those with foot or ankle pain due to injury or arthritis eliminating the need for these invasive surgeries.

Commonly Treated Ankle & Foot Conditions

We have listed a few of the most common ankle and foot issues below. If your condition doesn’t appear, reach out to us or fill out the Regenexx Candidate Form to find out if you can be treated with one of our non-surgical procedures.

  • Arthritis
  • Peroneal Tendon Tear or Split
  • Plantar Fasciitis
  • Ligament Sprain or Tear
  • Tarsal Tunnel Syndrome
  • Sub-talar Arthritis or Instability
  • Ankle Instability
  • Bunions

Foot & Ankle Outcomes


Prior to treatment, patients report being limited to an average of 56% of their optimal function. After receiving treatment, they report averages up to 72%. The functional questionnaire represented here is the Functional Rating Index (FRI).

Data updated March 01, 2021.


Prior to receiving treatment, patients report average pain of 4.6/10. One month after treatment, pain levels decrease to an average of 2.9/10, a decrease of 37%. The questionnaire used is the Numeric Pain Scale (NPS).

Data updated March 01, 2021.

Patients feel their joints are, on average, already 26% better after only 1-month, and continue to improve from there. The questionnaire used is the Single Assessment Numeric Evaluation (SANE).

Data updated March 01, 2021.

Regenexx® Procedures provide non-surgical treatment options for those suffering from pain related to osteoarthritis, joint injuries, spine pain, overuse conditions, and common sports injuries. These medical procedures are only performed by highly skilled doctors and are used to help reduce pain and improve function. Regenexx procedures have helped thousands of patients improve their quality of life, return to the activities they enjoy, and avoid the need for surgery or joint replacement*.

Regenexx Physicians represent a very selective, highly skilled, interventional orthobiologics network that is 100% focused on orthopedic conditions. All Regenexx physicians are musculoskeletal experts with extensive training and experience in the diagnosis and treatment of musculoskeletal conditions, as well as complex, image-guided injections of your body's own healing agents to treat orthopedic issues. Regenexx patient outcomes are tracked in a registry and with that information, we provide transparent outcome data for those who may be considering this treatment option.

Why Regenexx Procedures Are Effective


Bone Marrow Concentrate

Regenexx-SD is bone marrow concentrate that contains stem cells, which exist inside all of us in various tissues, ready to repair damage when it happens. As we get older or suffer serious injuries, our bodies may not be able to recruit enough of these cells to the site to repair the damaged area completely. The Regenexx-SD Procedure helps remedy this issue by extracting bone marrow from an area of the back of the hip that has a dense population of these important cells and then concentrating those cells prior to injecting them into the injured area using advanced imaging guidance. The aims of the procedure are to reduce pain and improve function by promoting the body's own ability to repair itself naturally. This patented bone marrow concentrate protocol can treat a wide range of orthopedic conditions. Your Regenexx doctor will evaluate your condition and your imaging to conclude whether a bone marrow concentrate or platelet-based treatment is the best option for your orthopedic condition.

Blood Platelet Treatments

Super Concentrated Platelet Rich Plasma and Advanced Platelet Lysate Procedures

Regenexx offers two platelet injection procedures – Platelet Rich Plasma (PRP) and Platelet Lysate Treatments – that enhance your body’s natural healing process by adding healing growth components from your own blood to your injured areas. PRP, in particular, is effective in repairing muscle, ligament, tendon, and joint injuries. The platelet injection treatments work with your stem cells, encouraging and supporting their efforts to heal damaged tissues, especially those related to spine conditions, arthritis and soft tissue injuries. Our advanced platelet procedures are superior to the ones provided at most regenerative medicine clinics because our machines yield purer and more concentrated platelet samples.

Treating Ankle Joint Instability, Ligament Tears and Sprains

If you have had an ankle injury, whether a bad sprain or a series of repeated minor sprains, your ligaments that connect your ankle bones together may have become stretched or partially torn. This results in a snowball effect that alters the way you walk, leading to stress on other parts of your foot and possibly to another ankle sprain. The good news is that Regenexx Platelet Rich Plasma (PRP) Procedures can strengthen loose ligaments and promote the healing of damaged tissues. If your ankle injury is deemed too substantial for this treatment, we may suggest our bone marrow concentrate protocol instead.

Alternatives to Ankle Fusion, Surgery and Replacement

Subsequent to an ankle injury, infection or trauma, osteoarthritis may develop. The articular cartilage, acting as a protective barrier between your bones, is usually smooth and fibrous. As this cartilage breaks down or is lost completely, arthritis comes into play, and the space between your bones lessens. We can see this early symptom of ankle osteoarthritis on an X-ray.   

The once smooth and thick cartilage thins and grooves form. In response, the bones around the cartilage grow thicker, protrude outward and create spurs. Synovium, the membrane that creates a viscous fluid that nourishes your cartilage and keeps it slippery, flares up and thickens. You may experience more swelling if the synovium produces more fluid than necessary.

This degenerative disease can often be tended to without relying on fusion, replacement or surgery – or the rehab that comes with those procedures. Regenexx Stem Cell and PRP procedures could relieve pain and enable patients to walk out of the clinic with little or no downtime.

Regenexx® Patient Success Stories